||Functional magnetic resonance imaging (fMRI) is the predominant modality for studying the mechanisms of brain function. By measuring changes in brain hemodynamics as they relate to mental operations, fMRI offers a wealth of possibilities for complementing traditional structural neuroimaging with physiological information. This has many implications in advancing our ability to understand and map human brain function and aiding disease research through the identification and characterization of related functional pathology. In this talk I will present some of our recent research at BiSICL on novel fMRI data analysis including activation detection, spatial characterization, network analysis and brain decoding. I will also discuss some application areas in neuro-degenerative disease, which is one of the main challenges facing health care systems in developed countries.