Alexandra Pacureanu

Contact Details

Office
Room 2140, House 2,
Polacksbacken (Lägerhyddsvägen 2), Uppsala

Telephone
+46(0)18 - 471 3465

Email
alexandracb.uu.se

Postal address
Centre for Image Analysis
Uppsala University
Box 337
SE-751 05 Uppsala
Sweden

Visiting
Travel directions to CBA
can be found here.

Publications

Journal papers

  1. Ke, R*, Mignardi, M*, Pacureanu, A, Svedlund, J, Botling, J, Wählby, C & Nilsson, M
    In situ sequencing for RNA analysis in preserved tissue and cells.
    Nature Methods, 10.1038/nmeth.2563, 2013/07/14/online, doi, 2013. Press release
  2. Varga, P, Pacureanu, A, Langer, M, Suhonen, H, Hesse, B, Grimal, Q, Cloetens, P, Raum, K & Peyrin, F
    Investigation of the three-dimensional orientation of mineralized collagen fibrils in human lamellar bone using synchrotron X-ray phase nano-tomography.
    Acta Biomaterialia, 2013/05/23/online, doi, 2013.
  3. Pacureanu, A, Larrue, A, Langer, M, Olivier, C, Revol-Muller, C, Lafage-Proust, M.-H, & Peyrin, F
    Adaptive filtering for enhancement of the osteocyte cell network in 3D microtomography images
    IRBM, Elsevier, Vol. 34, Issue 1, doi, 2013.
  4. Pacureanu, A, Langer, M, Boller, E, Tafforeau, P & Peyrin, F
    Nanoscale imaging of the bone cell network with synchrotron X-ray tomography: optimization of acquisition setup.
    Medical Physics, Vol. 39, Issue 4, doi, 2012.
  5. Langer, M*, Pacureanu, A*, Cloetens, P, Grimal, Q & Peyrin, F
    X-ray phase nanotomography resolves the 3D human bone ultrastructure.
    PLoS ONE, 7(8): e35691, doi, 2012.
  6. Pacureanu, A, Langer, M, Olivier, C, Grimal, Q & Peyrin, F
    Quantitative 3D imaging of the human bone lacuno-canalicular network with synchrotron radiation computed tomography
    Submitted, 2013.
  7. Langer, M, Cloetens, P, Pacureanu, A & Peyrin, F
    X-ray in-line phase tomography of multimaterial objects.
    Optics Letters, Vol. 37, Issue 11, pp. 2151-2153, doi, 2012.
  8. Ionescu, B, Ott, L, Lambert, P, Pacureanu, A, Buzuloiu, V, Coquin, D
    Tackling action-based video abstraction of animated movies for video browsing
    Journal of Electronic Imaging, Vol. 19, Issue 3, doi, 2010.

Peer reviewed conference papers

  1. Dong P, Pacureanu A, Zuluaga MA, Olivier C, Frouin F, Quentin G & Peyrin F
    A New Quantitative Approach for Estimating Bone Cell Connections from Nano-CT Images.
    Engineering in Medicine and Biology Society, IEEE International Conference of (EMBC), Osaka, Japan, in press, 2013.
  2. Varga P, Pacureanu A, Langer M, Hesse B, Peyrin F & Raum K
    Case specific finite element analysis of the strains experienced by osteocytes.
    V International Conference on Computational Bioengineering, Leuven, Belgium, in press, 2013.
  3. Langer M, Hesse B, Pacureanu A, Suhonen H, Cloetens P, Raum K & Peyrin F
    Extending validity of X-ray in-line phase tomography to heterogeneous objects.
    Colloque Traitement du Signal et des Images GRETSI'13, Brest, France, in press, 2013.
  4. Varga P, Pacureanu A, Langer M, Suhonen H, Hesse B, Grimal Q, Cloetens P, Raum K & Peyrin F
    The 3D orientation of mineralized collagen fibrils in human lamellar bone and its mechanical consequences.
    19th Congress of the European Society of Biomechanics, Patras, Greece, in press, 2013.
  5. Pacureanu, A., Rollet, J., Revol-Muller, C., Buzuloiu, V., Langer, M. & Peyrin, F.
    Segmentation of 3D cellular networks from SR-micro-CT images.
    Biomedical Imaging: From Nano to Macro, IEEE International Symposium on (ISBI), Chicago, USA, pp 1970-1973, 2011.
  6. Pacureanu, A., Revol-Muller, C., Rose, J. L., Sanchez-Ruiz, M., & Peyrin, F.
    A vesselness-guided variational segmentation of cellular networks
    Biomedical Imaging: From Nano to Macro, IEEE International Symposium on (ISBI), Rotterdam, The Netherlands, pp 912-915, 2010.
  7. Pacureanu, A., Larrue, A., Peter, Z. & Peyrin, F.
    3D non-linear enhancement of tubular microscopic bone porosities.
    Biomedical Imaging: From Nano to Macro, IEEE International Symposium on (ISBI), Boston, USA, pp 602-605, 2009.
  8. Peyrin, F., Pacureanu, A. & Langer, M.
    3D microscopic imaging by synchrotron radiation micro & nano-CT.
    Image Processing, IEEE International Conference on (ICIP), Brussels, Belgium, pp 3057-3060, 2011.
  9. Pacureanu, A., Langer, M., Dong P., Revol-Muller, C., Buzuloiu, V. & Peyrin, F.
    Imagerie microscopique 3D du réseau lacuno-canaliculaire dans l'os humain.
    Colloque Traitement du Signal et des Images GRETSI'11., 4 pages, Bordeaux, France, 2011.
  10. Peyrin, F., Pacureanu, A., Zuluaga, M.A., Dong, P. & Langer, M.
    3D X-ray CT imaging of the bone Lacuno-Canalicular Network.
    Biomedical Imaging: From Nano to Macro, IEEE International Symposium on (ISBI), Barcelona, Spain, pp 1788 - 1791 , 2012.
  11. Revol-Muller, C., Grenier, T., Rose, J.L., Pacureanu, A., Peyrin, F. & Odet, C.
    Region Growing: When Simplicity Meets Theory. Region growing revisited in feature space and variational framework
    Lecture Notes Series of Communications in Computer and Information Science (CCIS), Springer-Verlag, 20 pages, 2013.
  12. Langer, M., Cloetens, P., Hesse, B., Pacureanu, A., Raum, K., Lafage-Proust M.-H. & Peyrin F.
    Propagation based X-ray phase microtomography of multi-material objects for simultaneous bone and soft tissue visualisation.
    Biomedical Imaging: From Nano to Macro, IEEE International Symposium on (ISBI), Barcelona, Spain, pp 210-213 , 2012.
  13. Peyrin, F., Dong, P., Pacureanu, A., Zuluaga, M.A., Olivier, C., Langer, M. & Cloetens, P.
    Synchrotron radiation CT from the micro to nanoscale for the investigation of bone tissue.
    Proc. SPIE 8506, Developments in X-Ray Tomography VIII, doi:10.1117/12.939473, 2012.
  14. Revol-Muller, C., Rose, J.L., Pacureanu, A., Peyrin, F. & Odet C.
    Shape Prior in Variational Region Growing.
    IEEE International Conference on Image Processing Theory, Tools and Applications (IPTA), pp 116-120, 2012.
  15. Dong, P., Pacureanu, A., Zuluaga, M.A. & Peyrin, F.
    Quantification of Bone Cell Connections from 3D Nano-CT Images.
    European Society for Molecular Imaging : Hot Topics in Molecular Imaging (TOPIM), Les Houches, France, 2012.
  16. Ishaq, O., Negri, J., Bray, M., Pacureanu, A., Peterson R. & Wählby C.
    Automated Quantification of Zebrafish Tail Deformation for High-Throughput Drug Screening.
    Biomedical Imaging: From Nano to Macro, IEEE International Symposium on (ISBI), San Francisco, USA, in press, 2013.
  17. Zuluaga, M.A., Pacureanu, A., Dong, P., Orkisz, M. & Peyrin, F.
    Minimum Cost Path Approach for the Segmentation of Bone Canalicular Network from Nano-CT Images.
    IEEE Nuclear Science Symposium and Medical Imaging Conference, Valencia, Spain, 2011.
  18. Pacureanu, A., Larrue, A., Peter Z., Revol-Muller, C., Buzuloiu, V. & Peyrin, F.
    Filtrage 3D non-linéaire pour la détection de microstructures biologiques à l'échelle nanométrique.
    Colloque Traitement du Signal et des Images GRETSI'09, 4 pages, Dijon, France, 2009.
  19. Ionescu, B., Pacureanu, A., Lambert, P. & Vertan C.
    Highlighting action content in animated movies.
    Signals, Circuits and Systems, IEEE International Symposium on (ISSCS), Iasi, Romania, pp 1-4, 2009.

Other conferences

  1. Pacureanu, A., Ishaq, O., Allalou, A. & Wählby C.
    Making isotropic 3D imaging at microscopic scale accessible to every lab.
    BioImage Informatics, Oral presentation, Dresden, Germany, September 16 - 19, 2012.
  2. Pacureanu, A., Langer, M., Revol-Muller, C., & Peyrin F.
    Imaging of the Bone Cell Network with Nanoscale Synchrotron Radiation Computed Tomography.
    Swedish Symposium on Image Analysis, Oral presentation, Stockholm, Sweden, March 2012.
  3. Pacureanu, A., Peyrin F., Langer, M., Ishaq, O., Allalou, A. & Wählby C.
    Isotropic 3D imaging of biological specimens at micro and nano scale.
    Berlin-Brandenburg School for Regenerative Therapies Symposium on Visualization for Regenerative Medicine, Oral presentation, Berlin, Germany, December 5 - 7, 2012
  4. Pacureanu, A., Langer, M., Rose, J.L., Revol-Muller, C. & Peyrin F.
    3D nano-CT : a new approach for imaging at cellular scale.
    General Assembly of the French Society for Signal and Image Processing in Life Sciences, Oral presentation (Invited), Lyon, France, October 22 - 24, 2012
  5. Pacureanu, A., Ishaq, O., Allalou, A. & Wählby C.
    Optical microtomography as a 3D imaging technique accessible to every lab.
    Biomedical Imaging: From Nano to Macro, IEEE International Symposium on (ISBI), Poster, San Francisco, USA, accepted, 2013.
  6. Langer, M., Hesse, B., Pacureanu, A., Suhonen, H., Cloetens, P., Raum & Peyrin F.
    Priors for X-ray in-line phase tomography of heterogeneous objects.
    Swedish Symposium on Image Analysis, Oral presentation, Gothenburg, Sweden, March 2013.
  7. Cloetens, P., Suhonen, H., Bay, A., Bohic, S., Fleck, C., Langer, M., Pacureanu, A., Peyrin, F., Rack, A. & Vigneron J.P.
    Non-destructive and Multi-modal 3D Imaging of Biological Materials.
    MRS Spring Meeting, San Francisco, USA, 2012.
  8. Dong P, Pacureanu A, Zuluaga MA, Gouttenoire PJ, Olivier C & Peyrin F
    Quantification of Bone Cell Processes from Submicrometer Synchrotron Micro-CT Images.
    11th European Congress of Stereology and Image Analysis, Kaiserslautern, Germany, 2013.
  9. Langer, M., Cloetens, P., Hesse, B., Suhonen, H., Pacureanu, A., Raum & Peyrin F.
    Design of priors for X-ray in-line phase tomography.
    Biomedical Imaging: From Nano to Macro, IEEE International Symposium on (ISBI), Poster, San Francisco, USA, 2013.

Misc

Thesis prize - Biomedical Engineering "Imaging the bone cell network with nanoscale synchrotron computed tomography" Awarded by IEEE - EMBS France , SFGBM, AGBM and GDR Stic-Santé

Beauty of science Lacuno-canalicular network

Spotlight on science, ESRF

ESRF Highlights 2012

In situ RNA sequencing in preserved cells and tissues


Figure. A word cloud of my publications illustrating my area of research.