||Glaucoma is one of the most common causes of blindness in the world. Early detection and treatment of the disease improves the prognosis of the glaucoma patient. Progression of glaucoma can be assesed from comparing photographies of the optic disk and nerve head, taken at different points in time. Pathological changes in the optic disk, such as the loss of nerve fibre tissue, indicates progressed glaucoma.
In this master thesis, the goal has been to develop a tool that can facilitate the evaluation of glaucoma progression. By flickering (switching back and forth) two images of the optic disk, any structural changes to the disk should be readily visualized. Since the photographies are often mutually misaligned, succesful registration of the images is needed before the flickering. The registration is done using a statistical measure called mutual information as the similarity measure. Futhermore, various means of improving the visual quality of the images, such as noise reduction and contrast enhancement have been evaluated.