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Presentation Information     2006-04-06 (15:15)   •  The seminar room at Vi2

Speaker Duccio Fanelli
Comment CMB, Karolinska Institute
Type External presentation
Title Large-scale dynamics of antibodies from tomographic data
Abstract It is becoming increasingly evident that dynamics is a key feature of the biological functions of macromolecules. Proteins are by no means static objects and exhibit a variable degree of structural flexibility. Recent developments of single-molecule detection techniques now make possible modeling protein dynamics by resolving the relevant physical interactions directly from experimental measurements. We recently provided the first example of such innovative strategy by analyzing an ensemble of three-dimensional cryo-electron tomography (cryo-ET) individual reconstructions of Immunoglobulin G (IgG), and consequently building up a mechanical model of the protein. This experimentally-based model was then employed to inspect by means of Brownian dynamics simulations the entire pathway of a typical IgG-antigen reaction chain.