In English

Presentationsinformation     2008-05-05 (15:15)   •  The seminar room at Vi2

Talare Chandrajit Bajaj
Kommentar Computational Visualization Center, Department of Computer Sciences, Institute of Computational Engineering and Sciences, The University of Texas at Austin
Typ External presentation
Titel Image Analysis and Structure elucidation techniques for single particle cryo-EM versus cryo-ET
Sammanfattning With continued advances in three dimensional Electron Microscopy (3D EM) one is progressively able to elucidate the structural building blocks of proteins (and nucleic acids) at varying resolutions. In this talk, I shall discuss algorithms to detect the secondary structural motifs (helices and sheets) from proteins for which the volumetric 3D EM maps are reconstructed at 5-10 Angstrom resolution. Additionally, I shall show that when the resolution is coarser than 10 Angstrom, some of the tertiary structural molecular motifs can be elucidated from the 3D EM. For each of these algorithms, we employ techniques from computational geometry and differential topology, especially the computation of stable/unstable manifolds of certain critical points of distance functions of molecular surface boundaries.